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KMID : 0360220210620050595
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Journal of the Korean Ophthalmological Society
2021 Volume.62 No. 5 p.595 ~ p.604
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Correlation between Changes in Thyroid Stimulating Immunoglobulin Levels and Chorioretinal Vessels in Thyroid Eye Disease
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Lee Jae-Kyoung
Lee Dong-Cheol
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Abstract
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Purpose: To investigate the changes in retinal and choroidal vessels according to changes in thyroid stimulating immunoglobulin (TSI) in patients with thyroid eye disease (TED).
Methods: A total of 41 patients (82 eyes) with TED were enrolled. The subjects were divided into two groups: an experimental group with clinically significant TSI sample-to-reference ratio (%) abnormalities (> 140) and a control group. Within the experimental group, the median value of 451 was used to further classify patients into groups A and B. Using optical coherence tomography/ angiography, the sizes of the superficial fovea avascular zone (sFAZ) and deep fovea avascular zone, the diameter of the macular center 1 mm fovea, 3 mm parafovea superficial capillary plexus density (sCPD), deep capillary plexus density, choroidal thickness, and choroidal vascularity index were measured.
Results: In the experimental group, the change in the TSI value and the change in the 3 mm parafovea sCPD showed a significant positive correlation (p = 0.040) with a correlation coefficient of 0.307. Among group B patients of the experimental group, the changes in the TSI value and sFAZ showed a strong negative correlation (-0.417), but it was not statistically significant (p = 0.053).
Conclusions: In TED patients with clinically significant TSI levels (> 140), blood vessel density in the superficial layer of the 3 mm parafovea significantly increased with TSI. Especially in the high TSI (≥ 451) group, superficial retinal vessel density and choroidal blood flow increased with TSI level whereas the sFAZ tended to decrease due to compensation mechanisms.
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KEYWORD
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Graves ophthalmopathy, Optical coherence tomography, Retinal vessels, Thyroid-stimulating immunoglobulin
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